Cain has appeared as a regular on Hope & Faith and played the recurring character of Casey Manning on the hit series, Las Vegas. He had a lead role in the made-for-television disaster epic, 10.5: Apocalypse, then starred in another made-for-TV holiday romance, A Christmas Wedding, and the miniseries, Final Approach. In September Dawn (2007), his stepfather’s period drama on the Mountain Meadows Massacre in 1857, Cain had a small, but significant role as Joseph Smith, founder of the controversial Mormon Church. He has also starred in several popular films, including The Broken Hearts Club (2000), Out of Time (2003) and Bailey’s Billion$ (2004), co-starring Laurie Holden, Jennifer Tilly and Tim Curry.
Cain made a return to the Superman franchise, with a special guest role in a seventh season episode of Smallville as the immortal Dr. Curtis Knox, a character based upon the DC Comics villain Vandal Savage.
Cain was seen in the second half of Season 3 of Comic Book Menappearing at Kevin Smith’s Secret Stash where the crew was celebrating 75 years of Superman, citing that Dean Cain helped people care about Superman again. Currently, Dean can be seen on the popular Supergirl TV series starring Melissa Benoist as Kara Danvers, in which he plays Jeremiah Danvers, her foster dad.